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Professor, Cardiology
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Education

1989 M.D Yonsei University, College of Medicine, Korea 

1998 Ph.D Yonsei University, Graduate School of Medicine, Medical Science (Cardiovascular Biology)

1996 ECFMG certified

Postgraduate Training

1989 - 1990 Internship Yonsei University Medical Center, Seoul, Korea

1990 - 1994 Residency (Internal Medicine) Department of Internal Medicine, YonseiUniversity Medical Center, Seoul, Korea

1997 - 1999 Fellowship (Cardiology) Division of Cardiology,Yonsei University Medical Center, Seoul, Korea

2000 - 2002 Postdoctoral Fellow Division of Cardiovascular Research, St. Elizabeth’s Medical Center, Tufts University School of Medicine, Boston, USA

Academic Appointments

2002- Investigator, Caritas St. Elizabeth’s Medical Center, Division of Cardiovascular Research, Tufts University School of Medicine, Boston, USA

2003 - 2007 Assistant Professor, Department of Medicine, Tufts University School of Medicine, Boston, MA

2006 - Director of Stem Cell Biology at Caritas St. Elizabeth’s Medical Center

2007 - Associate Professor of Medicine, Tufts University School of Medicine, Boston, MA

2008 - Associate Professor of Medicine, Emory University School of Medicine, Atlanta, GA

Honors and Awards

2000 American Heart Association Fellowship Grant Award (New England Affiliate)

2000 Young Investigator Award, Finalist, at International Session of Annual Scientific Meeting of the Japanese Society of Circulation

2002 Young Investigator Award, Finalist, at 13th Annual Meeting of Society for Vascular Medicine and Biology, Boston, USA

2003 Scientist Development Grant, American Heart Association, National Center

2003 Earl Charlton Research Award for new faculty, Tufts University School of Medicine

2003 Melvin Marcus Young Investigator Award, Finalist, American Heart Association

2004 Young Investigator Award in Physiology, Pharmacology and Pathology, Finalist, American College of Cardiology

2006 Winner (Fellow, Hyun-Jai Cho), Basic Science Award, Caritas St. Elizabeth’s Medical Center Annual Research Day

2007 Winner (Fellow, Bianling Liu), Basic Science Award, Caritas St. Elizabeth’s Medical Center Annual Research Day

Link to Yoon Lab Website

Major interest of our team is to use stem cell technology to treat various cardiovascular diseases.

Stem Cells

 • We develop and use different bone marrow-derived stem or progenitor cells for cardiovascular repair

             o Bone marrow-derived multipotent stem cells (BMSC)

             o Endothelial progenitor cells

             o Mesenchymal stem cells

             o Hematopoietic stem cells

• Target diseases

             o Cardiac diseases: Myocardial infarction, chronic heart failure

             o Peripheral vascular disease; PAOD (peripheral artery obstructive disease) etc

             o Diabetic neuropathy

             o Lymphedema

             o Wound (wound healing)

• We investigate embryonic stem cells

             o differentiate into endothelial cells, cardiomyocytes, lymphatic vessels

             o therapeutic potential in the target diseases

• We recently started to combine technologies of biomaterial and stem cells for cardiac repair

Mechanistically, we are interested in angiogenesis, lymphangiogenesis, and cardiomyogenesis

Diabetes related research

• We work on the role of angiogenesis in diabetic complications such as heart failure, PAOD and diabetic    neuropathy

• We investigate functional defects of stem or progenitor cells in diabetes

             o Currently we are studying ROS-related targets

• We are developing a strategy to rescue this impairment

Research achievements

First demonstration of successful gene therapy with VEGF-C for treating secondary lymphedema (Yoon et al, J Clin Invest 2003)

Role of VEGF and EPCs in the development of diabetic cardiomyopathy (Yoon et al, Circulation, 2005)

First demonstration of side effects (calcification) of infarcted myocardium treated with unfractionated bone marrow cells (Yoon et al, Circulation 2004)

Development of novel bone marrow-derived stem cells and demonstration of successful therapeutic effects in myocardial infarction (J Clin Invest, 2005)

Role of host cells in therapeutic effects of adult stem cells (J Exp Med, 2007)

Publications & Presentations

1.    Tressel SL, Kim H, Ni CW, Chang K, Velasquez-Castano JC, Taylor WR, Yoon YS, Jo H. Angiopoietin-2 stimulates blood flow recovery after femoral artery occlusion by inducing inflammation and arteriogenesis. Arterioscler Thromb Vasc Biol. 2008;11:1989-95.

2.    Cho HJ, Lee N, Lee JY, Choi YJ, Ii M, Wecker A, Jeong JO, Curry C, Qin GJ, Yoon YS*. Role of host tissues for sustained humoral effects following endothelial progenitor cell transplantation in the ischemic heart. J Exp Med 2007; 204:3257-3269.

3.    Kirchmair R, Tietz AB, Panagiotou E, Walter DH, Silver M, Yoon YS, Schratzberger P, Weber A, Kusano K, Weinberg DH, Ropper AH, Isner JM, Losordo DW. Therapeutic angiogenesis inhibits or rescues chemotherapy-induced peripheral neuropathy: Taxol- and Thalidomide-induced injury of vasa nervorum is ameliorated by VEGF. Mol Ther 2007 ;15:69-75.

4.    Lee JY, Wecker A, Losordo D, Yoon YS*. Derivation and characterization of bone marrow-derived multipotent stem cells. Exp Hematol 2006;34:1602-3.

5.    Cho HJ, Yoon YS*. Synergism of hematopoietic cytokines for infarct repair. Circ Res 2006;98:990-992.