Education

• M.D., Michigan State University; 1983
• Internship and Junior Residency in Medicine, St. Joseph Mercy Hospital, University of Michigan Medical School, Ann Arbor, MI; 1983-1985
• Senior Residency in Internal Medicine, Carney Hospital, Boston University School of Medicine, Boston, MA; 1985-1986
• Clinical/Research Fellowship in Nutrition; Laboratory for Surgical Metabolism and Nutrition, Brigham and Women's Hospital and the Dana Farber Cancer Institute, Harvard Medical School, Boston, MA; 1986-1989
• Clinical/Research Fellowship in Endocrinology and Metabolism; Harvard Combined Endocrinology Training Program, Brigham and Women's Hospital, Joslin Diabetes Center and Beth Israel Hospital, Harvard Medical School, Boston, MA; 1989-1992

Academic and Clinical Involvement

• Associate Program Director, Emory General Clinical Research Center (GCRC)
• Site-specific Director, Emory University Hospital GCRC
• Co-Director, Emory Mentored Clinical Research Scholar Program ( K12 RR17643)
• Director, Center for Clinical and Molecular Nutrition, Department of Medicine
• Secondary appointment; Division of Digestive Diseases, Department of Medicine
• Secondary appointment; Instructor in Surgery, Department of Surgery
• Faculty in Nutrition and Allied Health; Emory Graduate Division of Biological and Biomedical Science
• Investigator, Emory Winship Cancer Institute
• Associate Director, Nutrition and Metabolic Support Service, Emory University Hospital, Atlanta, GA
• Outpatient nutrition/metabolism and bowel rehabilitation service, Emory Clinic, Atlanta, GA
• Editorial Boards: Journal of Parenteral and Enteral Nutrition; Clinical Nutrition; Current Opinion in Clinical Nutrition and Metabolic Care

Research Interests

• Molecular mechanisms and nutrient, growth factor and redox regulation of intestinal cell growth, repair, and function in clinical and translational models
• Mechanisms of action and metabolic/clinical effects of glutamine supplemented specialized nutrition support in critical illness
• Gut mucosal mechanisms and metabolic/clinical effects of modified diet, glutamine and specific growth factors in clinical and translational models of short bowel syndrome and inflammatory bowel disease

Recent Publications

1. Griffith DP, McNally T, Battey CH, Forte SS, Cacciatore AM, Szeszycki EE, Bergman GF, Furr CE, Murphy FB, Galloway JR, Ziegler TR. 2003 Intravenous erythromycin facilitates post-pyloric feeding tube placement in critically ill patients: A double-blind, randomized, placebo-controlled study. Critical Care Medicine 31: 39-44.

2. Fernandez- Estívariz C, Gu LH, Gu L, Jonas CR, Wallace TM, Pascal RR, Devaney KL, Jones DP, Farrell CL, Podolsky DK, Ziegler TR. 2003 Trefoil peptide expression and goblet cell number in rat intestine: effects of KGF and fasting/refeeding. American Journal of Physiology 284: R564-R573.

3. Ziegler TR, Fernández- Estívariz C, Gu LH, Fried MW, Leader LM. 2003 Severe villus atrophy and chronic malabsorption induced by azathioprine. Gastroenterology 124: 1950-1957.

4. Jonas CR, Gu LH, Nkabyo YS, Mannery YO, Avissar NE, Sax HC, Jones DP, Ziegler TR. 2003 Glutamine and KGF each regulate extracellular thiol/disulfide redox and enhance proliferation in Caco-2 cells. American Journal of Physiology 285: R1421-R1429.

5. Evans ME, Jones DP, Ziegler TR. 2003 Glutamine prevents cytokine-induced apoptosis in human colonic epitheilial cells. Journal of Nutrition 133: 3065-3071.

6. Lin E, Gletsu N, Fugate K, McClusky D, Gu LH, Zhu J-I, Ramshaw BJ, Papanicolaou DA, Ziegler TR, Smith CD. 2004 The effects of gastric surgery on systemic ghrelin levels in the morbidly obese. Archives of Surgery 139: 780-784.

7. Sitaraman SV, Liu X, Gu LH, Ziegler TR, Bado A, Merlin D. 2004 Colonic leptin: Source of a novel pro-inflammatory cytokine involved in IBD. FASEB Journal 18: 696-698.

8. Jones DP, Go YM, Anderson CL, Ziegler TR, Kinkade JM Jr, Kirlin WG. 2004 Cysteine/cystine couple is a newly recognized node in the circuitry for biologic redox signaling and control. FASEB Journal 18: 1246-1248.

9. Ouko L, Ziegler TR, Gu LH, Eisenberg LM, Yang VW. 2004 Wnt11 signaling promotes proliferation, transformation and migration of IEC6 intestinal epithelial cells. Journal of Biological Chemistry 279: 26707-26715.

10 . Avissar NE, Ziegler TR, Toia L, Gu L, Ray EC, Berlanga-Acosta J, Sax HC. 2004 ATB 0/ASCT2 expression in residual bowel after massive enterectomy and growth factor treatment in rabbits. Journal of Nutrition 124: 2173-2177.

11. Washizawa N, Gu LH, Gu L, Openo KP, Jones DP, Ziegler TR. 2004 Comparative effects of glucagon-like peptide-2 (GLP-2), growth hormone (GH) and keratinocyte growth factor (KGF) on markers of gut adaptation after massive small bowel resection in rats. JPEN Journal of Parenteral and Enteral Nutrition 28:399-409.

12. Alteheld B, Evans ME, Gu LH, Ganapathy V, Leibach FH, Jones DP, Ziegler TR. 2005 Alanylglutamine dipeptide and growth hormone maintain PepT1-mediated transport in oxidatively stressed Caco-2 cells. Journal of Nutrition 135:19-26.

13. Nkabyo YS, Go YM, Ziegler TR, Jones DP. 2005 Extracellular cysteine/cystine redox regulates the p44/42 MAPK pathway by metalloproteinase-dependent epidermal growth factor receptor (EGFR) signaling. American Journal of Physiology 289: G70-78.

14. Ziegler TR, Ogden LG, Singleton KD, Luo M, Fernandez-Estivariz C, Griffith DP, Galloway JR , Wischmeyer PE . 2005 Parenteral glutamine increases serum heat shock protein-70 in critically ill patients. Intensive Care Medicine 31: 1079-1086.

15. Evans ME, Jones DP, Ziegler TR. 2005 Glutamine inhibits cytokine-induced apoptosis in human colonic epithelial cells via the pyrimidine pathway. AmericanJournal of Physiology 289: G388-G396.

16. Kucharzik T, Hudson JT, Lugering A, Abbas JA, Bettini M, Lake JG, Evans ME, Ziegler TR, Merlin D, Madara JL, Williams IR. 2005 Acute induction of human IL-8 production by intestinal epithelium triggers neutrophil infiltration without mucosal injury. Gut 54:1565-1572.

17. Evans ME, Junqiang Tian, Gu LH, Jones DP, Ziegler TR. 2005 Dietary supplementation with orotate and uracil increases adaptive growth of jejunal mucosa after massive small bowel resection in rats. JPEN Journal of Parenteral and Enteral Nutrition 29:315-321.

18. Jeppesen PB, Sanguinetti EL, Buchman A, Howard L, Scolapio JS, Ziegler TR, Gregory J, Tappenden KA, Holst J, Mortensen PB. 2005 Teduglutide (ALX-0600), a dipeptidyl peptidase-IV resistant glucagon-like peptide-2 analog improves intestinal function in short bowel syndrome patients. Gut 54: 1224-1231.

19. Gletsu N, Lin E, Khaitan L, Lynch SA, Ramshaw B, Raziano R, Torres WE, Ziegler TR, Papanicolaou DA, Smith CD. 2005 Changes in C-reactive protein predict insulin sensitivity in severely obese individuals following weight loss surgery. Journal of Gastrointestinal Surgery 9:1119-1122.

20. Asamoah V, Kolachala V, Wang V, Ziegler TR, Merlin D, Sitaraman SV. 2005 TNF-alpha upregulates adenosine 2b (A2b) receptor expression and signaling in intestinal epithelial cells: a basis for A2bR overexpression in colitis. Cellular and Molecular Life Sciences 62:2647-2657.

21. Ziegler TR, Leader LM. 2006 Parenteral nutrition: Transient or permanent therapy in intestinal failure? Gastroenterology 130:S37-42.

22. Nkabyo Y, Gu LH, Jones DP, Ziegler TR. 2006 Deficient dietary sulfur amino acid intake oxidizes thiol/disulfide redox status in rat plasma and small intestinal and colonic mucosa. Journal of Nutrition (in press).