Highlighted Research

The Emory Department of Medicine is proud to boast a strong research program. Please review the information below for highlights of the research Emory Department of Medicine faculty are involved in.

Research Program Highlights  

Regenerative Engineering and Medicine (REM)

The Regenerative  Engineering and Medicine Research Center research center is a joint collaboration between Emory University and Georgia Tech. REM is specifically focused on endogenous repair or how the body can harness its own potential to heal or regenerate. Bone, muscle, nerves, heart, blood vessels, and other tissues each have a baseline ability to regenerate. REM investigators ask what can be done when trauma or disease in humans overwhelms the ability of tissues or organs to regenerate on their own.  

Some of the Emory regenerative engineering and medicine programs are:

  • Cell delivery
  • Cardiac regeneration
  • Critical limb ischemia
  • Cell reprogramming
  • Cell therapy

Learn more about Regenerative Medicine at Emory:

Microbiome

Dr.  Shanthi Srinivasan teamed up with other investigators at Emory and the University of Michigan to study the relationship between a “Western” (i.e. high-fat) diet, intestinal bacterial flora (i.e. microbiota), and NAFLD. They hypothesized that a diet high in fat, sugar, and cholesterol causes an imbalance in natural intestinal microbiota. This imbalance—called dysbiosis—leads to local inflammation and altered gut permeability. They recently extended these findings by showing that feeding a high-fat diet to mice lacking a protein important to intestinal epithelial permeability led to features in the liver also seen in NASH. The changes in liver histology were reversed by oral administration of antibiotics. These findings confirmed the link between a high-fat diet, intestinal microbiota and permeability, and NAFLD. Read full article.

Immunology

Abnormal immune responses are fundamental aspects of a wide spectrum of human diseases including multiple allergic and autoimmune conditions as well as cardiovascular, bone and malignant diseases. Therapeutic manipulation of immune responses is becoming a frequent part of today’s disease treatments.  A number of multidisciplinary groups in the Lowance Center for Human Immunology, the Fecal Transplant Center, the Emory Transplant Center, the Influenza Pathogenesis & Immunology Research Center and the Malaria Host-Pathogen Interaction Center are conducting immunology-based basic, translational, and clinical research. These highly collaborative studies include investigators from Emory School of Medicine, Yerkes Primate Center, Emory Healthcare, Children’s Healthcare of Atlanta, the Grady Health System, the Atlanta Veterans Affairs Medical Center, the Centers for Disease Control and Prevention and Georgia Institute of Technology with critical infrastructure provided by the Atlanta Clinical and Translational Science Institute (ACTSI). 

HIV/AIDS

The HIV/AIDS research program strives to improve treatment for HIV infection, develop approaches to possibly cure HIV, test methods to prevent HIV infection and to develop an effective HIV vaccine. The research also includes improving the effectiveness of currently available therapies through decreasing treatment disparities among populations and through increasing retention of infected patients in care. Much of the research is done through collaborations with the Rollins School of Public Health, the Emory Center for AIDS Research (CFAR), the Emory Vaccine Center, Children’s Healthcare of Atlanta, the Grady Health System, the Veterans Administration, the Centers for Disease Control and Prevention, and the countries of Georgia, Kenya, Rwanda, Thailand, and Zambia. Clinical trials for treatment, prevention and vaccine testing are primarily coordinated through the Emory-CDC HIV/AIDS Clinical Trials Unit (CTU).

Learn more: Emory Center for AIDS Research, Emory Vaccine Center, Emory-CDC HIV/AIDS Clinical Trials Unit (CTU), and Rwanda/Zambia HIV Research Group (RZHRG).